This invention provides for methods of increasing levels of healthy vaginal bacteria by treating the vaginal mucosa with bacteriocins derived from Lactobacillus paragasseri, Lactobacillus gasseri, and other bacterial strains. The bacteriocins are surprisingly advantageous as being selectively active against Lactobacillus iners but relatively inactive against H2O2-producing Lactobacillus species. Because L. iners is involved in the onset and maintenance of vaginal dysbiosis, selective removal of this bacterium from the vaginal microbiome treats or prevents conditions associated with vaginal dysbiosis, such as bacterial vaginosis and its sequelae.
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机译：本发明提供了通过将阴道粘膜与衍生自乳杆菌，乳酸杆菌，乳酸杆菌，酸杆菌和其他细菌菌株的细菌菌，增加健康阴道细菌水平的方法。 诱人的细菌素令人惊讶的是有利的，因为对乳酸杆菌是对乳酸杆菌而且相对无惰性的对抗H 2 O 2产生乳酸杆菌物种。 因为L. Iners参与了阴道失调的发作和维护，选择性地从阴道微生物组织治疗中去除这种细菌或防止与阴道脱泻病相关的条件，例如细菌性阴道病和其后遗症。
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