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BACTERIOCINS TO IMPROVE VAGINAL COLONIZATION OF HYDROGEN PEROXIDE PRODUCING LACTOBACILLUS FOR FEMALE REPRODUCTIVE HEALTH
BACTERIOCINS TO IMPROVE VAGINAL COLONIZATION OF HYDROGEN PEROXIDE PRODUCING LACTOBACILLUS FOR FEMALE REPRODUCTIVE HEALTH
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机译:细菌素可改善产生过氧化氢的乳酸菌对女性生殖健康的阴道定殖
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摘要
This invention provides for methods of increasing levels of healthy vaginal bacteria by treating the vaginal mucosa with bacteriocins derived from Lactobacillus paragasseri, Lactobacillus gasseri, and other bacterial strains. The bacteriocins are surprisingly advantageous as being selectively active against Lactobacillus iners but relatively inactive against H2O2-producing Lactobacillus species. Because L. iners is involved in the onset and maintenance of vaginal dysbiosis, selective removal of this bacterium from the vaginal microbiome treats or prevents conditions associated with vaginal dysbiosis, such as bacterial vaginosis and its sequelae.
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