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EVALUATION METHOD FOR GENOMIC ABNORMALITIES IN CELLS

机译:细胞基因组异常的评价方法

摘要

Disclosed is a method for evaluating if there are genomic abnormalities in cells being tested, the cells being tested being pluripotent stem cells cultivated in a culture medium or cells resulting from the induced differentiation of pluripotent stem cells, the method including a step of measuring the amount of an indicator present in the culture supernatant of the test cells, and a step of evaluating, on the basis of the amount of the indicator present, if there are genomic abnormalities in the test cells, wherein the indicator is at least one selected from the group consisting of deoxycytidine, kynurenine, putrescine, alanine, cysteine, cystathionine, and threonic acid, and whether or not there are genomic abnormalities in the test cells is evaluated on the basis of the amount of the at least one indicator present.
机译:公开了一种用于评估是否存在正在测试的细胞中存在基因组异常,该细胞被测试为在由多能干细胞的诱导分化中产生的培养基或细胞中培养的多能干细胞,该方法包括测量量的步骤 在测试细胞的培养上清液中存在的指示剂,以及在存在的指示剂的量的基础上评估,如果测试细胞中存在基因组异常,其中该指示剂是选自的至少一种 组由脱氧胞苷,犬藻素,腐粉,丙氨酸,半胱氨酸,胱硫脲和脱酸酸,以及是否存在测试细胞中的基因组异常,基于存在的至少一个指示剂的量评价。

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