首页>
外国专利>
SPLIT SINGLE-BASE GENE EDITING SYSTEMS AND APPLICATION THEREOF
SPLIT SINGLE-BASE GENE EDITING SYSTEMS AND APPLICATION THEREOF
展开▼
机译:分开单碱基基因编辑系统及其应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
Provided are two split single-base gene editing systems. Intein-mediated split BE3, saKKH-BE3 and ABE7.10 are separately developed by using the existing protein structure information of spCas9 and saCas9 and splitting methods thereof, and have targeted gene mutation efficiency equivalent to that of unsplit BE3, saKKH-BE3 and ABE7.10 working system, thereby making possible package into an AAV for delivery.
展开▼