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Inhibition of Diacylglycerol Kinase to Augment Adoptive T cell Transfer
Inhibition of Diacylglycerol Kinase to Augment Adoptive T cell Transfer
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机译:抑制二酰基甘油激酶增强养足T细胞转移
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摘要
The present invention provides compositions and methods for inhibiting one or more diacylglycerol kinase (DGK) isoform in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of DGK in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.
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