CHIMERIC ANTIGEN RECEPTORS TARGETING VARIANT III OF EPIDERMAL GROWTH FACTOR RECEPTOR

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to the field of biotechnology, in particular to a specific variant III of the epidermal growth factor receptor (EGFRvIII), a chimeric antigen receptor (CAR) containing an EGFRvIII-binding domain, a transmembrane domain and an intracellular signaling domain, as well as a polynucleotide encoding it. Also disclosed is a vector, a cell containing the above-mentioned polynucleotide. The invention also relates to an immune cell containing the above-mentioned polynucleotide, a method for its preparation, as well as a pharmaceutical composition containing it. ;EFFECT: invention makes it possible to effectively treat cancer. ;17 cl, 9 dwg, 10 tbl, 12 ex