Peripheral localized GABA positive allosteric modulators for the treatment of irritable bowel syndrome and other diseases in the peripheral nervous system

摘要

Problem to be solved: to provide a compound allosteric modulator of GABA-A receptor selectively targeting the peripheral nervous system and organ of the body and a compound and composition which do not pass the blood brain barrier.A compound having the following structural formula is shown.The compounds and compositions of the present invention include, for example, visceral pain, bowel movement, irritable bowel syndrome, functional abdominal pain, functional idiopathic diarrhea, inflammatory bowel disease, drug induced pain, bile salt absorption deficiency, lactase or other carbohydrate intolerance It is useful for the treatment of diseases or disorders mediated by GABA-A neuronal activity.Diagram