Systematic review of modulators of benzodiazepine receptors in irritable bowel syndrome:Is there hope?

摘要

Several drugs are used in the treatment of irritable bowel syndrome(IBS) but all have side effects and variable efficacy.Considering the role of the gut-brain axis,immune,neural,and endocrine pathways in the pathogenesis of IBS and possible beneficial effects of benzodiazepines(BZD) in this axis,the present systematic review focuses on the efficacy of BZD receptor modulators in human IBS.For the years 1966 to February 2011,all literature was searched for any articles on the use of BZD receptor modulators and IBS.After thorough evaluation and omission of duplicate data,10 out of 69 articles were included.BZD receptor modulators can be helpful,especially in the diarrhea-dominant form of IBS,by affecting the in? ammatory,neural,and psychologic pathways,however,controversies still exist.Recently,a new BZD receptor modulator,dextof isopam was synthesized and studied in human subjects,but the studies are limited to phase □b of BZDs in IBS,but bearing in mind the concentrationdependent effect of BZDs on cytokines and cell proliferation,future studies using pharmacodynamic and pharmacokinetic approaches are highly recommended.