Virusreceptorer: En Litteratursammanstaellning (Virus Receptors: A Review).

摘要

The present report reviews the literature on virus receptors. Viruses infect and survive in the human host by invading specific host cells. The attachment is mediated by the interaction of a viral surface protein (VAP) with specific components of the host cell membrane. Information is accumulating rapidly on the nature of viral receptors and on the specific domains involved in binding, which might be proteins, lipid or carbohydrate moieties. The report discusses the prospect of using receptors to block the virus-receptor interaction as a mechanism to prevent virus infection. Such therapy may become practice within 5-10 years. The usefulness of virus receptors as sensing elements in biosensors is also discussed. Membrane based biosensors, which use intact receptor molecules, may be a reality in the future, while soluble receptors or anti-receptor antibodies can be used in biosensors with the present technology.