embedded image The salt is crystalline or amorphous phosphate, or crystalline or amorphous oxalate. Particularly, a crystal form B of the phosphate of the present invention has high crystallinity, low hygroscopicity and good stability, and the crystal form B of the phosphate is good in oral bioavailability, good in tolerance after long-term administration, difficult to induce hypoglycemia and good in inhibition effect on serum DPPIV."/> Salt of cetagliptin, preparation method thereof, pharmaceutical composition, and use thereof
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Salt of cetagliptin, preparation method thereof, pharmaceutical composition, and use thereof

机译:西匹齐敏盐,其制备方法,药物组合物及其用途

摘要

The present invention relates to a salt of a compound of formula (I),; embedded image The salt is crystalline or amorphous phosphate, or crystalline or amorphous oxalate. Particularly, a crystal form B of the phosphate of the present invention has high crystallinity, low hygroscopicity and good stability, and the crystal form B of the phosphate is good in oral bioavailability, good in tolerance after long-term administration, difficult to induce hypoglycemia and good in inhibition effect on serum DPPIV.
机译:本发明涉及式(I)化合物的盐,; <化学ID =“Chem-US-00001”> “嵌入式图像”文件=“US11046701-20210629-C00001.gif”他=“37.08mm”ImgContent 盐是结晶或无定形磷酸盐,或结晶或无定形草酸盐。特别地,本发明的磷酸盐的晶体形式B具有高结晶度,低吸湿性和良好的稳定性,并且磷酸盐的晶体形式B在口腔生物利用度良好,长期给药后耐受性,难以诱导低血糖症良好抑制对血清DPPIV的抑制作用。

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