A method for constructing an internal exposure model of a perfluorinated compound of a zebrafish embryo, comprising the following steps: establishing a platform for a microinjection system; formulating a sample solution containing a perfluorinated compound, the perfluorinated compound comprising one or more of perfluorocarboxylic acid compounds and perfluorosulfonic acid compounds; and selecting a zebrafish embryo in the cleavage stage, and using the platform for the microinjection system to inject the sample solution into a vegetal pole of the zebrafish embryo. The construction method can construct an internal exposure model, and enable the accurate quantitative perfluorinated compound to be directly injected into the vegetal pole of the zebrafish embryo in the cleavage stage to obtain a more direct, stable, and accurate internal exposure model used for predicting the embryo developmental toxicity of the perfluorinated compound. Also provided is an application of an internal exposure model of a perfluorinated compound of a zebrafish embryo, comprising a method for evaluating the embryo developmental toxicity of the perfluorinated compound.
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