The present disclosure relates to a method for continuous and noninvasive estimation of mixed venous blood saturation [SvO2] in a mechanically ventilated subject (3). The method comprises the steps of measuring (S1; S10) an expiratory carbon dioxide [CO2] content in expiration gas exhaled by the subject, measuring (S2; S20) an expiratory flow or volume of expiration gas exhaled by the subject, estimating (S3; S30) a cardiac output [CO] or an effective pulmonary blood flow [EPBF] of the subject from the measured expiratory CO2 content and the measured expiratory flow or volume using a capnodynamic Fick method, and estimating (S4; S40; SvO2 based on the estimated CO or the EPBF of the subject.
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