Drug evaluation method using reconstituted cancer tissue

摘要

Provides a method for identifying molecules involved in cancer resistance.We also provide a method for identifying effective drugs for cancer resistance.In addition, the drug is effective for the recurrence cancer.The expression level of EMT related molecules before and after administration of the anticancer drug is measured in the cancer cell and / or stromal cell in the tissue which reconstructs the cancer microenvironment, and it is judged that EMT related molecule which rises after the administration of the anticancer drug is concerned with the resistance to the cancer. Screening of molecules involved in resistance to cancer.In cancer cells and / or stromal cells in tissue that reconstruct cancer microenvironmentsThe expression level of EMT related molecules before and after administration of anticancer drugs was measured.It is concluded that EMT related molecules, which have elevated expression levels after administration of anti-cancer drugs, are involved in the resistance to cancer.It is judged that the substance which can inhibit the function of the EMT related molecule is an effective drug for the treatment resistance of the cancer.Screening method for effective drug resistance.Treatment and / or prophylactic treatment of recurrent tumors with an anticancer drug and an inhibitor targeting nochch3 signal.