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TARGETED CONTRAST AGENTS FOR MRI OF AMYLOID DEPOSITION
TARGETED CONTRAST AGENTS FOR MRI OF AMYLOID DEPOSITION
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机译:淀粉样蛋白沉积MRI的靶向造影剂
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摘要
A liposomal composition (“ADx-001”) is provided, ADx-001 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand. The macrocyclic gadolinium-based imaging agent may be conjugated to a fourth phospholipid.
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