Biomedical implants comprising surface-modified inorganic nanoparticles and biodegradable polymers, and preparation method thereof

摘要

It relates to a biotransplant comprising surface-modified inorganic particles and biodegradable polymers, and a method for manufacturing the same, wherein the inorganic particles according to an aspect neutralize acidic decomposition products generated when the biodegradable polymer is decomposed, thereby causing cell inflammation due to acidification. By inhibiting reaction, free radicals, apoptosis, necrosis and aging, the biocompatibility of biotransplants can be improved.After growing monomers on the surface, the modified content is increased by secondary surface modification with hydrophobic polymers of various molecular weights. , Due to the hydrophobic polymer on the surface, it may exhibit high dispersion stability characteristics in an organic solvent.