BIOMEDICAL IMPLANT COMPRISING SURFACE-MODIFIED INORGANIC NANOPARTICLE AND BIODEGRADABLE POLYMER, AND PREPARATION METHOD THEREFOR

摘要

The present invention relates to a biomedical implant comprising surface-modified inorganic particles and a biodegradable polymer, and a preparation method therefor. The inorganic particles according to an aspect neutralize acidic lysates generated upon the degradation of the biodegradable polymer to inhibit cellular inflammatory response, reactive oxygen species, apoptosis, necrosis, and senescence caused by the acidification, thereby improving the biocompatibility of the biomedical implant. After growth of monomers on the surface, the polymer is secondarily subjected to surface modification with hydrophobic polymers having various molecular weights so that the modification content increases. The hydrophobic polymers on the surface can lead to high dispersion stability in organic solvents.