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WOUND TREATMENT GEL OBTAINABLE BY COMBINING PLATELET RICH PLASMA WITH AUTOLOGOUSLY DERIVED THROMBIN
WOUND TREATMENT GEL OBTAINABLE BY COMBINING PLATELET RICH PLASMA WITH AUTOLOGOUSLY DERIVED THROMBIN
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机译:伤口处理凝胶可以通过将血小板富血浆与自体衍生的凝血酶组合来获得
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摘要
The present invention provides a method of making a wound treatment composition, wherein the method comprises; i) fractionating a whole blood sample into multiple samples including a platelet rich plasma (PRP) sample, a platelet poor plasma (PPP) sample and a erythrocyte sample, wherein the PRP sample has a haematocrit level of 1-10%, ii) processing a portion of the PPP and/or PRP sample to facilitate cleavage of autologous pro-thrombin present in the PPP and/or PRP to produce autologous thrombin, and iii) combining the PRP sample with a portion of the PPP sample and a portion of the thrombin produced in step (ii) to produce the wound treatment composition; wherein step ii) is performed at less than 15° C. In preferred embodiments the PRP has a haematocrit level of 2 or 8%. Wound treatment compositions produced by the methods are also provided as are compositions for use in treating chronic and acute wounds.
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