PDGF and VEGF aptamers with improved stability and their use in the treatment of PDGF and VEGF-mediated diseases and disorders

摘要

PROBLEMTION PROBLEMTION: Apluter that binds to platelet-derived growth factor B (PDGF-B including PDGF-BB and PDGF-AB), vascular endothelial growth factor (VEGF including VEGF-121 and VEGF-165), and Provided are an aptamer construct comprising an aptamer that binds PDGF-B and an aptamer that binds to VEGF. A nucleic acid molecule comprising a nucleic acid sequence consisting of a specific sequence, wherein at least one of positions 8, 9, 15, 16 and 17 of the nucleic acid molecule contains a phosphorothioate bond or moiety, and position 1 is the nucleic acid. The nucleic acid molecule which is the first nucleoside from the 5'end of the molecule and where H and V are considered as the single position for counting the position of the nucleic acid molecule. [Selection diagram] None