Compositions and methods for fractal assembly of micron-scale nucleic acid structures

摘要

Compositions and methods of the present disclosure provide for staged assembly of nucleic acid microstructures made of an array of x number of polynucleotide tiles, where each of the polynucleotide tiles is a polygon configuration and is made from a single-stranded helical polynucleotide scaffold and a plurality of single-stranded polynucleotide staple strands of y number of unique staple sequences corresponding to the selected tile configuration, the y number of unique staple sequences capable of being constant for any value of x.