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ESTER NITRATES DERIVATIVES OF AROMATIC ALDEHYDES WITH MULTIPLE PHARMALOGIC PROPERTIES TO TREAT SICKLE CELL DISEASE

机译:酯硝酸盐具有多种药剂学性质的芳香族醛衍生物治疗镰状细胞病

摘要

The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.
机译:本发明提供了新的芳香族醛化合物,其具有更大的效力,增加Hb对氧气的亲和力,更大的防止镰刀的效力,以及改善SCD的其他症状的额外药理学性质。本发明进一步提供了通过提供具有根据本发明化合物的SCD的受试者来治疗SCD的方法。

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