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Adhesin tip multiepitope fusion antigen platform and vaccines and their use in the treatment of enterotoxigenic diarrhea
Adhesin tip multiepitope fusion antigen platform and vaccines and their use in the treatment of enterotoxigenic diarrhea
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机译:粘蛋白尖端多孔雀融合抗原平台和疫苗及其在肠毒素腹泻治疗中的用途
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摘要
The application provides for MEFA constructs and vaccines against Enterotoxigenic Escherichia coli (ETEC). Methods for reducing the incidence of diarrhea associated with ETEC are also provided. The representative adhesin tip MEFAs and the representative major subunit CFA MEFA-II provided in the disclosure has an adhesin tip backbone or major subunit CFA with one or more adhesin tips, adhesin subunit or major structural subunit epitopes incorporated onto the backbone. The adhesin tip MEFAs and the CFA MEFA-II provided advantageously prevents the ETEC molecule from attaching to the intestine.
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