adhesin tip multiepitope fusion antigen platform and vaccines and their use in the treatment of enterotoxigenic diarrhea

摘要

The present invention relates to enterotoxigenic Escherichia coli (etec) mefa vaccines and constructs. Methods for reducing the incidence of diarrhea associated with etec are also provided. Representative adhesin tip mefs and representative major subunit mefa-cfa provided in the description have a major subunit adhesin or cfa tip structure with one or more adhesin tips, adhesin subunit, or incorporated major structural subunit epitopes. in the structure. The adhesin-tipped mefa and the mefa-cfa provided advantageously prevent the etec molecule from binding to the gut.