A Mura compensation optimization method and system for liquid crystal display panel is disclosed. The method detecting the received original picture data signal and determining whether an original picture is a grayscale transition picture or a single grayscale value picture by a timing controller; and when determining that the original picture is a grayscale transition picture or not a single grayscale value picture, turning off a Mura compensation function by the timing controller. The present invention can avoid the phenomenon of display abnormality caused by Mura compensation under some specific screens, and optimize the Mura compensation effect of the liquid crystal display panel.
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