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COMPOSITIONS AND METHODS FOR CANCER TREATMENT BY ENHANCING ANTITUMOR IMMUNITY USING TANNIC ACID-BASED NANOCAPSULES
COMPOSITIONS AND METHODS FOR CANCER TREATMENT BY ENHANCING ANTITUMOR IMMUNITY USING TANNIC ACID-BASED NANOCAPSULES
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机译:通过使用鞣酸纳米胶囊提高抗肿瘤免疫性来治疗癌症治疗的组合物和方法
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摘要
The present disclosure generally relates to a composition matter and a method for cancer treatment comprising albumin (alb) coated tannic acid-Fe nanoparticles (NPs) with a therapeutic compound, and one or more diluents, excipients or carriers. In particular, the present invention provides a treatment by enhancing antitumor immunity using tannic acid-based nanoparticles containing a therapeutic cancer treatment that can induce immunogenic cell death (ICD). The method disclosed herein provides a potential solution to the immunotoxicity accompanying the ICD cancer immunotherapy by intratumoral or intravenous administration of a nanocapsule formulation of carfilzomib (CFZ), an ICD-inducing proteasome inhibitor, using interfacial supramolecular assembly of tannic acid (TA) and iron, supplemented with albumin coating for better metabolic stability.
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