Provided herein is a method of treating low turnover renal osteodystrophy in a subject being administered an agent that reduces bone turnover comprising measuring a level of one or more miRNAs in a sample from the subject. The miRNA being measured can include miRNA-30b, miRNA-30c, miRNA-125b and miRNA-155. Administration of the agent that reduces bone turnover can be stopped if the level of the one or more miRNAs measured is lower than a level of the one or more miRNAs measured in a control subject. Administration of the agent that reduces bone turnover can be continued if the level of the one or more miRNAs measured is not lower than a level of the one or more miRNAs measured in a control subject.
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