The present invention provides a mixture of prenylated flavonoids, stilbenes or both with flavans or curcuminoids or both, the mixtures controlling joint inflammation, joint pain, joint stiffness, cartilage deterioration, motility, range of motion , Flexibility, physical function of the joint, or a combination thereof. Prenylated flavonoids, stilbenes or mixtures of both with flavans or curcuminoids or both may optionally be used in other joint care agents, e.g., nonsteroidal anti-inflammatory/painkillers, COX/LOX inhibitors, glucosamine compounds, neuropathy. It can be used in combination with pain relievers.
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