CAR-T cells engineered to homing into the B cell region of the lymph nodes, skin, or gastrointestinal tract

摘要

PROBLEM TO BE SOLVED: To provide a genetically modified cell containing a receptor for homing a cell expressing a receptor to a specific anatomical region, a specific tissue, or a specific cell type, for example, a B cell region of a lymph node, a gastrointestinal tract, or the skin. Offer. SOLUTION: The T cells express (i) a B cell region homing receptor which is CXCR5, or a gastrointestinal homing receptor which is α4β7 or CCR9, and (ii) a chimeric antigen receptor (CAR). , The T cell, wherein the B cell region homing receptor or gastrointestinal homing receptor is not normally expressed by the T cell. [Selection diagram] None