Provided herein is a T lymphocyte comprising: (i) a skin homing receptor, a gastrointestinal homing receptor or a B cell zone homing receptor; and (ii) a chimeric antigen receptor (CAR). Also provided herein is such a T lymphocyte for use a method of treating a skin or a gastrointestinal tumor or cancer. Also provided herein is a method of generating a population of T lymphocytes, wherein a plurality of said T lymphocytes home to skin tissue or skin cells or gastrointestinal tract; and wherein said method comprises engineering a population of T lymphocytes to express a skin or a gastrointestinal homing receptor, respectively.
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