Process for the preparation of dicarbamate of methyl - 2. - butyl - 2 propanediol - 1,3 and its derivatives diacylated, and new acylates thus obtained

摘要

2-Methyl -2- (1-methylpropyl)-1, 3-propanediol dicarbamate is prepared by reacting methoxyacetone with the Grignard compound from a s-butyl halide, separating the resulting 2, 3-dimethyl -1- methoxypentan -2- ol and heating it to 50-150 DEG C. in the presence of a strong acid to form 2, 3-dimethylpentanal-1 (characterized as its 2, 4-dinitrophenylhydrazone), condensing this with formaldehyde in a strongly alkaline medium, separating the resulting 2-methyl -2- (1-methyl-propyl)-1, 3-propanediol (characterized as its bis-p-nitrobenzoate) and reacting it either with ethyl urethane in the presence of an aluminium alcoholate or with urea in the presence of copper acetate or lead acetate. N,N1-diacyl derivatives of the dicarbamate are obtained by reacting it with acetic, propionic or butyric anhydride in the presence of a condensing agent at a temperature not above 145 DEG C. They are useful as hypensive and sedative agents.