Improvements in or relating to polyfunctional unsymmetrical compounds

摘要

Novel compounds of the formula ROCH2CH(R1)-A1(Z-A11)n-R11 wherein R represents hydrogen, C1- 6 alkyl or C2- 7 alkanoyl; R1 represents hydrogen or C1- 6 alkyl; A1 and A11 represent -CS-, -CO-, -SO-, -SO2- or FORM:1043343/C2/1 R111 represents a substituted or unsubstituted alkyl or aralkyl radical; Z represents alkylene, aralkylene, FORM:1043343/C2/2 (in which Y is a divalent organic radical), the residue of a heterocyclic diamine FORM:1043343/C2/3 (in which the two nitrogen atoms are part of the heterocyclic ring D), FORM:1043343/C2/4 n is 0 or 1; R11 is FORM:1043343/C2/5 and A is a polar residue derived from a reagent of weak nucleophilic character, i.e. those which have an anion of a strong acid (dissociation constant greater than 10-5) or a cation of a weak base (dissociation constant less than 10-5), are prepared by reacting a compound of the formula FORM:1043343/C2/6 (wherein X represents a halogen atom) with a reagent of weak nucleophilic character. Alternatively, compounds in which X in the above formula represents a hydroxyl group may be reacted with a sulphating agent and subsequently with a neutralizing agent. Speciafied A groups are sulphate, thiosulphate, acetate, pyridinium, benzyldimethylammonium, isoquinolinium and picolinium. 2 - Chloroethyl 21 - hydroxyethyl sulphone, 2-methoxyethyl chloride and 2-methoxyethyl 21-chloroethyl sulphone are prepared by reacting bis - (2 - hydroxyethyl) sulphone, 2 - methoxy-ethanol and 2-methoxyethyl 21-hydroxyethyl sulphone respectively with thionyl chloride. 2 - Methoxy - ethyl 21 - hydroxyethyl sulphide is prepared by reacting 2-mercaptoethanol with 2-methoxyethyl chloride. 2 - Methoxyethyl 21 - hydroxyethyl sulphone is prepared by H2O2 oxidation of 2-methoxyethyl-21-hydroxyethyl sulphide. 2 - Methoxyethyl 21 - hydroxyethyl ethyl sulphonium bromide is prepared by reacting 2-bromoethanol with 2-methoxyethyl 21-hydroxyethyl sulphide.