Tricycloalkylidene peroxides - from 1-hydroxy-1'-hydro peroxydicyclohexyl peroxide or 1, 1'-dihydroperoxydicycloalkyl peroxi

摘要

Tricycloalkylidene peroxides are prepd. by reacting 1-hydroxy-11-hydroperoxydicyclohexyl peroxide or a 1,11-dihydroperoxydicyloalkyl peroxide with a cyclic ketone in an organic solvent contg. a strong acid catalyst. The rings may carry substituents. Dicyclohexylidene-2-methylcyclohexylidene peroxide, dicyclohexylidene octylidene peroxide, dicyclohexylidene cyclododecylidene peroxide, dicyclohexylidene-3-methyl-5-methoxycyclohexylidene peroxide, dicyclododecylidene cycloheptylidene peroxide and dicyclododecylidene cyclopentylidene peroxide are claimed. The peroxides are intermediates for macrocyclic products. They can also be used to crosslink polymers and as polymerisation initiators. They have antiparasitic, esp. antimalarial, activity. Solid ketones can be used. New peroxides can be obtained in high yield. The peroxide soln. obtained can be used directly for the conversion to macrocyclic cpds.