SCHIFFS BASES FROM 2-AMINOIMIDAZOLE DERIVATIVES AND THE PREPARATION THEREOF

摘要

1315575 2-Amino-imidazoles GRUPPO LEPETIT SpA 12 Oct 1971 [20 Nov 1970] 47488/71 Heading C2C Novel compounds of Formula I and their numeral acid salts where R represents hydrogen, alkyl, hydroxyalkyl or halogenoalkyl, RSP1/SP represents hydrogen or aryl, RSP11/SP represents hydrogen, C 1-8 alkyl hydroxy C 1-8 alkyl or halogeno C 1-8 alkyl, RSP111/SP represents a nitro substituted thienyl or furyl group and n = 0 or 1 are prepared by reacting a hydrochloride of a compound of Formula III with a solution of an equi-molar amount of an aldehyde of general formula in a mixture of ethanol and methanol in the presence of a strong base. Compounds of Formula I have a high degree of anti-microbial activity and form with a pharmaceutically acceptable carrier a pharmaceutical composition which may be administered orally, parenterally or topically.