Alpha - carboxyl - 2 - thienyl methyl penicillins and alpha - carboxyl - 2 - thienyl methyl cephalosporins, as well as their esters and basic salts, and production method thereof

摘要

1381160 Penicillin and cephalosporin derivatives PFIZER Inc 29 Aug 1972 [24 Feb 1972] 40078/72 Heading C2C Novel compounds having one of the general formulµ in which R is H or a 1-C 2-5 -alkanoyl-C 1-4 alkyl group and salts and esters thereof are prepared by reacting 6-aminopenicillanic acid or 7- amino cephalosporanic acid or an ester thereof with 2-thienyl-malonic acid in the presence of a water-soluble carbodiimide in a reaction unit solvent at ambient temperature. Pharmaceutical compositions for oral, parenteral and topical administration may be formulated comprising the above compounds in association with conventional diluents, excipients and carriers.