Process for preparing a compound selected from the group of 2 (tri fluoro methyl) - oxide 6 8 di - chlorine - 6R benzo pyrimidine E2 (DI fluoro methyl oxide (R1) 4 5 6) R2 7 (8) R3 benzo pyrimidine and their salts.Metals and amines alcoil

摘要

1301319 Quinazolines PFIZER Inc 13 Nov 1970 [13 July 1970] 54241/70 Heading C2C Compounds of formula wherein R 1 is F, Cl or C 1-4 -perfluoroalkyl, R 2 and R 3 are each H, Cl, Br, I, -CN, -NO 2 , phenyl, -OH, -NH 2 , -CONH 2 , -SO 2 NH 2 , C 1-2 - perfluoroalkyl, -SOR 4 , -SO 2 R 4 , -OCOR 4 , -NHCOR 4 , -CONHR 4 , -SO 2 NHR 4 , -CONHR 4 R 5 or -SO 2 NR 4 R 5 , in which each of R 4 and R 5 is C 1-4 -alkyl, or -NR 4 R 5 forms a C 4-8 -heterocycle, X is oxygen or sulphur, and R 6 is C 1-5 -alkyl and, when X is oxygen or sulphur, alkali metal or strong organic base salts thereof, are prepared by (a) acylation of an anthranilic acid, followed by cyclization of the amide with ammonia, (b) acylation of an anthranilamide, followed by cyclization of the amide by heating, (c) conversion of X from oxygen to sulphur by phosphorus pentoxide, (d) conversion of a thione to a thioether by an alkyl iodide, or (e) reduction of a nitro group R 2 or R 3 to an amino group, followed by acylation. The products are herbicides.