PREPARATION OF PLUS-3R-N-MONOMETHYLAMINO-4C-PHENYL-4T-ETHOXYCARBONYL-CYCLOHEXENE-1 ITS L- OR D-0,0-DIBENZOYL-TARTRATE

摘要

1344960 (+) - 3r - N - monomethylamino- 4c - phenyl 4t - ethoxycarbonylcyclohex - 1 - ene WARNER-LAMBERT CO 26 June 1972 [30 June 1971] 29846/72 Heading C2C The novel title compound and acid addition salts thereof such as the hydrochloride and the D- or L-o,o-dibenzoyltartrates are prepared by resolution of the receamic compound with an optically active o,o-dibenzoyltartaric acid or by monodemethylation of (+)-3r-N-dimethylamino - 4c - phenyl - 4t - ethoxycarbonylcyclohex- 1-ene by bromination in a chlorinated hydrocarbon at - 15‹ to 20‹ C. followed by treatment with water. Pharmaceutical compositions in conventional forms for oral, rectal or parenteral administration and having analgesic activity comprise the above novel compound or a salt thereof and a carrier or diluent.