process for the production of (cis - 1.2 - epoxypropyl) - phosphonsaeure, its salts, esters and diamide.

摘要

A method for the preparation of (+/-) and (-) (cis-1,2-epoxypropyl)phosphonic acid and its salt, amide and ester derivatives via the reaction of a 2-oxy substituted n-propylphosphonate or diamide analog with a reagent capable of effecting ring closure. The (+/-) and (-) (cis-1,2-epoxypropyl)phosphonic acid product thus obtained and its salts are antimicrobial agents which are useful in inhibiting the growth of gram-positive and gram-negative pathogenic bacteria.