THE PRODUCTION OF COVALENTLY CARRIER-BOUND PENICILLIN ACYLASE

摘要

1387459 Insolubilized penicillin acylase BAYER AG 22 Nov 1972 [23 Nov 1971] 53890/72 Headings C3H and C3P Penicillin acylase covalently bonded to a polymer of acrylamide, N,NSP1/SP-methylene-bisacrylamide and maleic acid in the anhydride form is obtained by contacting an aqueous solution of penicillin acylase at pH 5 to 6À5 at below 20‹ C. for at least 3 hours. The carrier may be prepared by heating a copolymer of acrylamide, N,NSP1/SP-methylene-bis-acrylamide and maleic acid under reduced pressure, e.g. for not more than 2 hours at 180‹ C.