Procedure for the obtaining of new 8 - (i- (2,3-dihydro-2-benzofuril) -alquil) -1,3,8-triazaespiro (4,5) -decanos. (Machine-translation by Google Translate, not legally binding)

摘要

Procedure for obtaining new 8- [1- (2-3-dihydro-2-benzofuryl) -alkyl] -1,3,8-triazaspiro (4,5) deans of general formula I **(See formula)** wherein Ph signifies a 1,2-phenylene residue, each of the residues R1, R2 and R3 signifies hydrogen or lower alkyl, each of the residues alk1 and alk2 signifies lower alkylene, which separates the nitrogen atom from the atom of spiro carbon by two ring carbon atoms, R4 signifies hydrogen, an aliphatic, araliphatic or aromatic moiety, R5 signifies two hydrogen atoms, hydrogen and lower alkyl or oxo, and R6 signifies hydrogen, lower alkyl or hydroxyalkyl lower, their acyl derivatives, N-oxides, quaternary ammonium compounds and salts, characterized by that compounds of general formulas III and IV **(See formula)** wherein a) X signifies a reaction-capable esterified hydroxy group, and Y signifies imino or b) X signifies amino and Y signifies two reaction-capable esterified hydroxy groups, and where all other general symbols have the meaning indicated above or a metal salt of these amines or imines, they are condensed to each other and, if desired, a obtained compound is transformed into another compound according to the present invention, or a obtained compound is transformed into its salts, acyl derivatives, N-oxides or compounds quaternary ammonia, and/or, if desired, a obtained salt is transformed into the free compound, and/or, if desired, a mixture of obtained isomers or racemates, are separated into the different isomers or racemates, and/or, if desired, the racemates obtained are dissociated in the optical antipodes. (Machine-translation by Google Translate, not legally binding)