NEW 15-SUBSTITUTED PROSTANOIC ACID DERIVATIVES AND PROCESSES FOR THEIR MANUFACTURE

摘要

Cpds of formula (I): (where one of R1 and R2 is H and the other is free or functionally modified OH, or R1+R2 is free or functionally modified oxo; R3 is free or functionally modified OH; one of R4 and R5 is CF3 and the other is free or functionally modified OH; R6 is 5-10C alkyl or alkenyl; R7 are H or together form a bond; A is vinylene) and their optical isomers, salts and esthers are new. They can be prepd. e.g. by reacting a cpd (II): with X1(CH2)4COOH (where X1 is a phosphonium gp).