A process of production of the crystalline form and relatively insoluble in cephalexin monohydrate water. (Machine-translation by Google Translate, not legally binding)

摘要

A process for the production of the crystalline and relatively water-insoluble form of cephalexin monohydrate, whose process is characterized in that it consists of preparing an acidic, concentrated aqueous solution of cephalexin with a ph of less than 2.4, adding enough N-butanol to form two liquid phases and then slowly neutralizing said biphasic system, up to about ph 4.0 to 5.0 at a temperature not higher than 45ºC to precipitate the water-insoluble crystalline form of cephalexin monohydrate. (Machine-translation by Google Translate, not legally binding)