Process for the preparation of steroidal spirolactones and intermediates

摘要

The present invention relates to a process for the preparation of steroidal spirolactones having the formula WHEREIN R1 is a linear alkyl having 1 to 4 carbon atoms and R2 is hydrogen or methyl comprising the steps reacting a compound of the formula WHEREIN R is alkyl having 1 to 4 carbon atoms and R2 is defined above, with a thioalkanoic acid of the formula R1COSH wherein R1 is defined above, heating the resultant product in a neutral media and recovering said steroidal spirolactones as well as the intermediates.