Radioactive iodine (131 -, 123-. 125 - Or 132 - iodine) dicarbonsaeureanilide containing, the metal - or amine salts, process for the preparation of these compounds and those containing radioactive function diagnostics

摘要

Prepns. contg. cpds. of formula (I): (where R1 = H, carboxy, N-acylamino, N-acylaminomethyl, N-alkyl-N-acylamino, N-butyrolactamyl or R3R4N-CO-; R3 and R4 are same or different H, lower alkyl or hydroxyalkyl; or R3+R4+N may form a heterocyclic residue opt. contg. another hetero-atom; X = opt. branched hydrocarbon (max 14C) opt. contg. one or more of -O or -S and salts of (I) with physiologically-acceptable basis are prepd. by heating cpd. (I) to be labelled with a possibly carrier-free alkali- or alkaline earth-radioactive iodide in aq. soln. or in a melt of one or more low-melting cpds. such as N,N-dimethyl-p-toluene-sulphonamide, dimethylsulphone etc. (I) may be used as diagnostic aids for the estimation of liver functions as well as for the presentation and functional diagnosis of bile ducts and gall-bladder. (I) has a short half-life in blood and liver, gives better differentiated curve and higher contrast and has 1/3 shorter duration of investigation than when using other diagnostics. No enterohepatic circulation occurs.