Antitumour compsn. - consisting of lysteria monocytogenes culture in pasteur nutrient broth

摘要

Antitumour compsns. consist of a culture Listeria monocytogenes, pref. obtd. by dissolving lyophilised Listeria monocytogenes powder in a nutrient broth, e.g. Pasteur broth. The culture pref. contains 50-100 million bacteria per 10 ml. The powder contains, e.g. 85% of live bacteria of attenuated activity. The bacteria may be obtd. from brain cells of still-born foeti. In an example, ascites liquid was removed from mice suffering from sarcoma B.P. 8 and replaced by either Pasteur broth or Pasteur broth contg. Listeria monocytogenes by subcutaneous injection in both cases. Ten control animals died in 39-68 days, whereas those injected with a culture according to the invention were cured. Physiological examination in these cases showed few tumour cells and no infection.