A method for the production of 2,2,2 - of trifluoroacetic acid ethyl difluoro methyl ether

摘要

Trifluoroethanol and chlorodifluoromethane are reacted in the presence of an alkali metal hydroxide and a co-solvent system comprising water and one or more of N-methyl pyrrolidone, dimethyl sulfoxide, tetramethylene sulfone or diethyleneglycol dimethyl ether, to yield 2,2,2-trifluoroethyl difluoromethyl ether. N-methyl pyrrolidone is a preferred solvent.