Antiarthritic and antirheumatic medicaments - contg. (1)-ribofuranosyl (1,2,4)-triazole (3)-carboxamide derivs.

摘要

The medicaments contain furanosyltraizole cpds. of formula (I):- In this formula, R1, R2 and R3, are H, acyl (pref. acetyl or propionyl), or phosphoric acid residues the further acidic functions of which may be presents in salt form and/or esterified in such a way that R1+R2 or R2 +R3 forms a phosphate residue. (I) exert a genuine antiarthritic or antirheumatic effect and can be used in the treatment of arthrtitis or rheumatic disorders when the known agents (which ameliorate symptome only cannot be administered or are ineffective. In the chromic adjuvant arthritis test, (I; R1=R2-R3=H) is active when administered in a dosage of 55mg/kg p.o. twice daily. The pred. cpd. (I) is 1-(beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide. Dosage units pref. contain 100-250 mg (I).