Method for local immunization against dental caries

摘要

Immunization against dental caries by local administration, in the vicinity of the oral mucosa of an animal susceptible to dental caries, of a vaccine containing a polyfructan or polyglucan polysaccharide, or a levansucrase or dextransucrase enzyme. The polysaccharides may be administered in purified form, or may be in the form of dead cells of the streptococci by which they are elaborated. Polyglucan polysaccharides so useful are produced by elaboration of strains of the species S.mutans and S.sanquis, while the polyfructan which may be incorporated in the vaccine may be an elaboration product of Streptomyces Strain SS2.