Process for the preparation of (+, -) - cis-alpha- (3- (2,6-dimethyl-1-piperidinyl) -alfaphenyl-2-pyridinemethanol, or acid addition salts thereof

摘要

(+,-)-cis- alpha -(3-(2,6-Dimethyl-1-piperidinyl)propyl)- alpha -phenyl-2-pyrid ylmethanol of the formula I and its acid addition salts. To prepare these compounds, pyridyllithium can be reacted with cis- gamma -(2,6-dimethylpiperidino)butyrophenone or cis-1-(3-lithiopropyl)-2,6-dimethylpiperidine with 2-benzoylpyridine. Pharmaceutical compositions comprising (+,-)-cis- alpha -(3-(2,6-dimethyl-1-piperidinyl)propyl)- alpha -phenyl-2-pyridylm ethanol and its acid addition salts can additionally be used for the treatment of cardiac arrhythmias. IMAGE