New procedure for the preparation of benz derivatives (f) indazol -4, 9-diona, with citostatic activity (Machine-translation by Google Translate, not legally binding)

摘要

PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF BENZ [F] INDAZOL-4,9-DIONA, WITH CYTOSTATIC ACTIVITY OF GENERAL FORMULA: ** FORMULA ** IN WHICH R1 R2 X MAY BE DIFFERENT ATOMS OR RADICALS. FIRST THERE IS THE REACTION CATALYZED BY THE ACID BENZ [F] INDAZOL-4,9-DIONA OR 3-CARBETOXI-BENZ [F] INDAZOL-4,9-DIONA WITH AN ALPHA CYCLE ETHER, TO PROVIDE A MIXTURE OF TWO COMPOUNDS. THE REACTION IS CARRIED OUT WITH A SOLVENT THAT MAY BE ETHYL ACETATE OR ACETONITRILE AND USING P-TOLMENSULFONIC ACID OR TRIFLUOROACETIC ACID AS A CATALYST. LATER THERE IS A SEPARATION AND PURIFICATION OF THE TWO COMPOUNDS OBTAINED. THESE COMPOUNDS TREATED WITH AN AMMONIA DISSOLUTION GIVES PLACE TO THE DESIRED COMPOUNDS. (Machine-translation by Google Translate, not legally binding)