L-homoserine prepn. by fermentation - of Brevibacterium flavum B-1006 or Corynebacterium glutamicum B-1505

摘要

L-Homoserine prepn. involves deep culture of threonine-dependent Brevibacterium flavum or Corynebacterium glutamicum under aerobic conditions, in which the strains used are B-flavum B-1006 or C. gluamicum B-1505. The new mutants give higher yields of about 20g/litre and a cheaper product on cheaper media. B. flavum B-1006 is obtd. by U.V. light and ethylene-imine-induced mutation of B. flavum ATCC 14067; C. glutamicum, B-1505 is obtained by nitrosoguanidine-induced mutation of C. glutamicum ATCC 13032. The product is produced on both synthetic and natural complex media, such as molasses, protein hydrolysates etc..