process for the production of 1 - substi - tuierter 8 - iodine - 6 - phenyl - 4h - triazolo (3,4c) thieno (2,3e) 1.4 - diazepines and their salts

摘要

The 1-substituted 8-iodo-6-phenyl-4H-s-triazolo[3,4c]thieno[2,3e]1,4-diazepines of the formula I, as well as their physiologically tolerated acid addition salts, are prepared by cleaving a 4,1-oxazepine of the formula VII at the oxygen atom by treatment with a strong mineral acid, adding a phosphorus or sulphur halide to the hydro halide which forms, reacting the dihalide thus obtained with ammonia or substances giving rise to ammonia, and dehydrogenating the product. The substituents in the formulae I and VII have the meanings given in Patent Claim 1. Further preparation processes are given in Patent Claims 7 to 11 and 13. The compounds exhibit valuable therapeutic properties, in particular tranquillising, tension-releasing and sedative activity, as well as an intensive anticonvulsive effect, in association with extraordinarily low toxicity. In addition, they can be employed for improving feed uptake in mammals. IMAGE